Reasons why you saw no results after three treatments of Apgujeong Rejuran Healer – What apgujeong dermatologist says about the real cause

✍️ Kim Young-gyun | Director of Core Dermatology Clinic · Board-certified Dermatologist (License No. 106824)
April 2026 | Based on clinical experience + academic data

“Director, I've looked at so many Rejuran Healer reviews in Apgujeong online.
But some people say their skin has completely changed, while others say they just wasted their money.
Why are the results so different for the exact same procedure?”

✅ Conclusion first

Some people don't feel any changes even after three sessions of Apgujeong Rejuran Healer, while others say “my skin has changed” after just two sessions. The difference isn't in the equipment or the price, but in just one thing — whether your skin concerns match Rejuran's indications. If you don't confirm this beforehand, you could end up wasting money, time, and recovery periods.

5 Things You Must Know Before Getting Rejuran Healer in Apgujeong

Hello. This is Kim Young-gyun, CEO and Director of Core Dermatology.

You've probably heard of Apgujeong Rejuran Healer at least once.
But when I listen to the people who come to pick them up, more people than you might think don't know exactly what procedure it is.

I'll share just one checkpoint at the end of this post.
If you only check this, you won't be swayed by any dermatology consultation.
I've worked as a dermatologist for 15 years and have seen many misunderstandings about Rejuran Healer in Apgujeong.
Today, I will honestly organize that story for you.

Apgujeong Rejuran Healer, what exactly is the principle behind how it changes the skin?

To be honest, the Apgujeong Rejuran Healer is not a procedure that ‘fills something in,’ but rather a procedure that stimulates the skin's self-healing power.

This is different from fillers or Botox, which create immediate volume or inhibit muscles.
Let me explain why that difference is important.

What happens when salmon DNA enters the skin?

The core ingredient of Rejuran Healer is PN (Polynucleotide).
These are DNA fragments extracted from salmon testes (so-called milt).

Why is this salmon?
Salmon DNA structure is quite similar to human DNA structure.
Thanks to this, the ingredient is gaining attention because it has a low rejection rate within the human body and high biocompatibility.

When this PN component is injected into the dermis of the skin (the second layer beneath the skin's surface)
It works in two ways.

The first pathway is the cell regeneration pathway.
PN stimulates fibroblasts in the dermis (the cells that create skin elasticity)
Induces the new creation of collagen and elastin.
Just like a rubber band stretches out when it gets old, the elastic fibers in your skin also loosen as you age.
Apgujeong Rejuran Healer doesn't directly replace these loose fibers,
This is how to restart the factory that makes new fibers (fibroblasts).

The second pathway is the angiogenesis pathway.
Simply put, blood circulation in the skin is promoted.
If blood flow improves, the skin receives increased oxygen and nutrient supply, and,
Your skin tone naturally brightens and its resilience improves.
Reference: Polynucleotides in Aesthetic Medicine — A PMC/NCBI Review

In addition to that, it has anti-inflammatory effects.
When inflammation decreases, skin troubles subside, and the damaged skin barrier gradually recovers.

What's the difference between PN and PDRN? Sorting out confusing ingredients.

This is a question I get asked very often in the clinic.
“Director, are Rejuran Healer and salmon injections different?”

To get straight to the point, they are ingredients from the same source, but their concentrations and molecular sizes differ.

PDRN (Polydeoxyribonucleotide) is a small DNA fragment purified from salmon DNA.
It is an ingredient that was first used in medical settings, such as wound healing and bedsore treatment, in the past.

PN (Polynucleotide) is a component with a larger molecular weight, which is PDRN compressed at a high concentration.
The key ingredient in Rejuran Healer is this PN.
Because it stays and acts in the dermis for a longer time
Current clinical observations suggest that the skin regeneration effect may be more long-lasting.
Reference: Rejuran Official Site — Same Pharma

For your reference, the Rejuran Healer product line in Apgujeong is categorized by purpose as follows:.

• Rejuran Healer (Black)PN 20mg/cc, Basic formulation for overall skin regeneration and elasticity improvement
• Rejuran IFor eye area, designed with low molecular weight to be suitable for sensitive eye surroundings.
• Rejuran SA formulation for pinpoint application on indented acne scars.
• Rejuran HB: PN + 히알루론산 + 리도카인(마취 성분) 조합 — 통증이 약 56% 줄었다는 보고가 있습니다 Reference: SmartSkin Clinic — Rejuran Formulation Comparison

[Director Kim Young-kyun's Comment]
“When I consult, I consider the choice of formulation to be quite important.
For example, if someone is concerned about fine lines under their eyes, using a general filler isn't the right approach.
Because there's a separate formulation for the eye area, like Rejuran I.
Even with the same name ‘Rejuran,' the formulation and application area are
It can make the results quite different.”

Apgujeong Rejuran Healer is a regenerative skin booster that stimulates fibroblasts in the skin's dermis with PN components derived from salmon DNA, promoting new collagen production.

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What skin concerns is Rejuran Healer effective for, and when should expectations be managed?

To get straight to the point, Apgujeong Rejuran Healer is strong for skin that needs ‘regeneration and repair,‘ but if your goal is 'volume, pigment, or lifting,' you may not achieve the desired results with it alone.

If you receive a procedure without knowing this distinction,
When you don't feel the effects, you conclude that “Rejuran isn't good in the first place.”.
But it wasn't that Rejuran was bad, it's just that it wasn't the right indication.

This can be helpful for people like this.

Due to Korea's climate characteristics, fine dust and yellow dust during the spring and fall transitions, and the dry indoor heating environment during winter
Many people are suffering from a broken skin barrier and inner dryness.

If you are experiencing the following concerns, Apgujeong Rejuran Healer may be of practical help.

• People with severe dryness deep within their skinIf your skin feels tight no matter how much moisturizer you apply. The Apgujeong Rejuran Healer is on a different level than surface moisturization because it draws moisture up from the dermis itself.
• For those concerned about fine lines caused by drynessIf you've been told you have a lot of fine lines for your age, or if your fine lines around your eyes and mouth become more prominent when you're dry, there may be improvement through moisture replenishment and stimulation of collagen production.
• Those with acne scars or skin damageWhen using the Rejuran S formulation, you can expect it to play a supportive role in skin regeneration around indented scars. (However, for deep scars, laser treatments like fractional laser are generally recommended first.)
• For those with dull and lifeless skin toneAs blood flow improves due to the angiogenesis effect, skin radiance is often restored. This is especially noticeable for those whose faces have lost their vitality due to lack of sleep or stress.
• Someone whose skin recovery is diminishedFor skin that easily reddens or becomes sensitive to irritation due to environmental or age-related factors. It can help strengthen the skin barrier.

Conversely, if you have concerns like these, we recommend other procedures first.

By the way.
There are cases where it is difficult to see results with Apgujeong Rejuran Healer.
I believe that hospitals that are honest about these aspects are ultimately reliable hospitals.

• When pores have enlarged due to saggingWhen skin elasticity decreases, pores stretch into an oval shape. Because Regena filler in Apgujeong does not have a lifting effect, lifting procedures like Ultherapy or Shurink are prioritized for such pores. Realistically, Regena filler should only be used as a supplementary treatment. Reference: Cheongdam Anz Dermatology Clinic — Rejuran: When It Works and When It Doesn't
• Pigmentation concerns like melasma, blemishes, and frecklesApgujeong Rejuran Healer does not directly destroy pigmentation. While it does provide a brightening effect by hydrating the skin, if you are hoping to fade melasma, you should primarily undergo pigment-specialized treatments such as laser toning or IPL.
• Deep nasolabial folds, cheek hollowness, and other volume-related issuesThis is a procedure that physically fills volume, like hyaluronic acid fillers. If you try to address it with Rejuran Healer in Apgujeong, it will be difficult to feel the desired level of improvement.

[Director Kim Young-kyun's Comment]
“Many people who come for their first consultation believe that Rejuran is a cure-all.
I'll be frank with you on the spot.
If your main concerns are pores or melasma, with just the Apgujeong Rejuran Healer,
You may find it difficult to feel as much change as you want.
I believe my role is to first guide you to treatments that suit your concerns.
Rather than first suggesting combinations that can charge more for the procedure,
”It's best to start with what your skin needs most right now."

One-line summary: Apgujeong Rejuran Healer is strong for dryness, fine wrinkles, and skin regeneration, but it has limitations for pore enlargement, pigmentation, and volume issues, so appropriate combining treatments may be necessary.

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Why did some people say that Apgujeong Rejuran Healer was “ineffective”?

To be honest, cases where there's a problem with Rejuran Healer in Apgujeong itself are rare. Most of the time, it's due to one of three reasons: insufficient treatment sessions, unrealistic expectations, or a mismatch in indications.

Misconception 1 — Did you judge me after only meeting me once?

Apgujeong Rejuran Healer is not a treatment that shows immediate results.
However, many people say after their first treatment, “I don't think there's much of a difference.”.

How about thinking of it this way?.
It's like expecting to gain muscle after working out for just one day.

Rejuran Healer in Apgujeong works by stimulating fibroblasts, waiting for new collagen to be generated.
It takes time for cells to activate, new cells to grow, and for that to be noticeable on the skin's surface.
Typically, you will start to feel the effects after completing 3-4 treatments at four-week intervals.
Reference: SmartSkin Clinic — Reasons why Rejuran is ineffective

In the first one to two sessions, you'll first notice changes like “improved skin radiance and makeup application.”.
Improvements in elasticity and fine wrinkles appear gradually in the next stage.

Misconception 2 — Have you heard that Rejuran solves all skin concerns?

As I mentioned before, this part is really important.
Apgujeong Rejuran Healer is the ‘professional player for regeneration.".

If you're concerned about pores or melasma, come to Apgujeong for the Rejuran Healer.
Then, of course, you won't feel an effect.

It was placing the player in an unexpected position.

In a 2016 study of five Korean women,
After receiving 4 treatments of PN filler every 2 weeks,
In their thirties, improvements in pores and skin thickness were observed, while in their forties, improvements in skin tone, wrinkles, and sagging were observed.
Reference: Park KY et al. Dermatologic Therapy 2016

As the research shows, the improvements are in skin texture, thickness, and tone.
It's good to keep in mind that pore size and pigment aren't directly targeted.

Misconception 3: Did you expect results the very next day after the procedure?

Sometimes people say things like this.
“I got a shot yesterday, but my skin looks worse.”

This is normal. Really.

Rejuran Healer is a procedure where more than 70 to 80 injections are directly administered into the skin.
Temporary swelling, small injection marks (papules), and redness immediately after the procedure are natural healing responses.
Most subside within 2 to 3 days.

Some people misunderstand this reaction as a ‘side effect" and stop the procedure, but,
Actually, the recovery process itself is linked to the mechanism of action of Rejuran Healer.
Reference: PS Medical HK — Post-Rejuran Treatment Instructions

[Director Kim Young-kyun's Comment]
“After 15 years in clinical practice, I've noticed a commonality among people who say, ‘It didn't work.".
Most cases are when people make a decision after just one treatment, or when they receive a procedure that doesn't suit their concerns.
I have something important to tell you.
Apgujeong Rejuran Healer is like sending a ‘long letter’ to your skin.
It's not an immediate response, but over time, the skin slowly responds.
”Those who give it enough time eventually feel the effects."

1-line summary: If you didn't feel the effects of Rejuran Healer in Apgujeong, it's recommended to first check three things: insufficient treatment sessions, mismatch of indications, and the expectation of immediate results.

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How many Rejuran Healer treatments are needed, and how long do the results last?

To get straight to the point, the recommended basic number of Rejuran Healer treatments is 3 to 4 sessions at 4-week intervals, and it is generally recommended to follow up with a maintenance treatment once every 6 months to a year.

Plan your recommended frequency and intervals this way.

3-4 times at 4-week intervals — this is the basic setup.

But to be honest, depending on your skin condition, you might need more.
For those who already have deep fine lines or whose skin has become very thin.
More than 5 treatments may be necessary,
You can expect more efficient results if you receive elasticity-improving treatments such as Thermage or Ultherapy concurrently.

The duration of the effect varies by individual.
However, maintenance effects are often observed within one year after the initial procedure is completed.,
It can vary depending on lifestyle habits (UV exposure, smoking, sleep patterns) and skincare routine.
Reference: SmartSkin Clinic — Reasons why Rejuran is ineffective

It's best to know from the beginning that the effect is not permanent.
If a hospital doesn't inform you beforehand, I recommend looking into it more closely.

Precautions on the day of the procedure and recovery period

The day of the procedure and post-procedure care significantly impact the results.

Precautions on the day of and after the procedure:

• After the procedure Swelling, redness, and small injection marksis a natural reaction and usually subsides within 2-3 days.
• On the day of the procedure, refrain from strenuous exercise, long baths, and saunas, or any activities that raise your body temperature.
• It is recommended not to arbitrarily touch or press the injection site.
• Because the skin barrier is temporarily weakened after the procedure Sufficient moisturizing and UV protectionIt is essential. Be sure to carry sunscreen with SPF 50 or higher, especially during the spring when UV rays intensify.
• It's best to avoid makeup on the same day and start lightly from the next day.
  Reference: PS Medical HK — Post-Rejuran Treatment Instructions

I will also be honest about the pain.
Apgujeong Rejuran Healer is quite a painful procedure because it involves injecting over 70 to 80 locations across the entire face.
You can significantly reduce the pain by applying enough numbing cream beforehand.
If you are very concerned about pain, you can consider the Rejuran HB formulation which contains lidocaine.

[Director Kim Young-kyun's Comment]
“Patients often ask about the maintenance cycle,
On my personal standard, I tend to recommend about once every six months.
Because skin continues to age.
To maintain the skin condition after the first treatment
Consistent management is much more efficient.
than receiving it all at once and resting for a long time
Sticking to the proper schedule is a much wiser choice in the long run.”

In summary: For Apgujeong Rejuran Healer, plan for 3-4 initial treatments every 4 weeks, followed by maintenance care every 6 months to 1 year. Thoroughly moisturizing and protecting your skin from UV rays after the procedure directly impacts the results.

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Before getting a Rejuran healer in Apgujeong, what should you absolutely check?

If I sum it up in one line, whether it's an MFDS-approved product, whether a doctor performs the procedure directly, and whether the formulation is decided through individual consultation — these three should be the criteria for choosing Rejuran Healer in Apgujeong.

How to check if a product is approved by the Ministry of Food and Drug Safety

Rejuran Healer is classified as both a medical device and a pharmaceutical product, and only products approved by the domestic Ministry of Food and Drug Safety (MFDS) can be used.
The Rejuran product line currently officially approved in Korea is manufactured and supplied by Same Pharma.
Reference: Rejuran Korea Official Website
Reference: MFDS Medical Device Information Portal

Nowadays, as Rejuran's patent has expired, many similar PN preparations have entered the market.
I recommend you definitely check what products are used in places where the prices are significantly lower.

When you consult, ask like this.
“Is the Rejuran you are using an MFDS-approved product?”
This one question can confirm many things.

Core Dermatology performs the Rejuran Healer in Apgujeong as follows.

At Core Dermatology, we always conduct a 1:1 skin consultation before the Rejuran Healer procedure in Apgujeong.
This consultation will first assess your current skin dryness, the depth of fine wrinkles, your skin barrier's condition, and your main concerns.

The formulation is also decided at this stage.
It's not appropriate to use a general hydrator for someone whose main concern is fine lines around the eyes.
We sometimes recommend the HB formulation first if you are combining Rejuran I and Healer, or if you are concerned about pain.

Dr. Kim Young-gyun, a dermatologist with 15 years of experience, performs the procedures himself.
Injection depth, injection volume, and procedure pattern are all aspects that can vary depending on the doctor's skill, which can lead to different results.
We also recommend checking this part during your consultation.

[Director Kim Young-kyun's Comment]
“To be perfectly honest,
There are dermatology clinics in Apgujeong that are good at Rejuran Healer.
There's one thing I want to emphasize.
When you consult, ask ‘Is this procedure right for my skin right now?’ first.
‘A place that explains the specific reasons, rather than just saying 'Yes, it fits', is a trustworthy place.
I'd appreciate it if you could also evaluate Core Dermatology by that standard.”

Key criteria for choosing a Rejuran Healer clinic in Apgujeong are: whether the product is MFDS-approved, whether the procedure is performed by a dermatologist, and consultation for personalized formulation.

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If you are considering Rejuran Healer in Apgujeong, be sure to first consult with a dermatologist to confirm that your skin concerns align with Rejuran's indications before the procedure.

“Instead of ”Everyone else is getting it, so I should too,“ the question, ”Is this the right procedure for my skin right now?" can completely change the outcome.

At Core Dermatology, with 15 years of experience as a dermatologist, rather than immediately recommending a procedure during the initial consultation, we first discuss what is most necessary for your current skin condition.

I am honest with those for whom the Apgujeong Rejuran Healer is not suitable, and I carefully guide those for whom it is suitable, from the choice of formulation to the treatment cycle.

I hope you'll consider carefully and double-check before making a decision based solely on reviews and price.

Thank you for reading the long text.

Sincerely, Kim Young-gyun, Chief Director of Core Dermatology

⚠️ Legal Notice This content is medical information prepared in compliance with medical law and medical advertising review standards. The treatment effects mentioned in the text may vary depending on individual skin condition, number of treatments, and post-treatment care, and do not guarantee specific results. Please consult a dermatologist before undergoing any treatment.

📚 References

• Polynucleotides in Aesthetic Medicine — PMC/NCBI Academic Review
• Park KY et al. PN Filler Skin Rejuvenation Study — Dermatologic Therapy 2016
• SmartSkin Clinic — Reason Why Rejuran Has No Effect (Doctor Reviewed)
• Cheongdam Anz Dermatology — Rejuran: When it's effective and when it's not
• PS Medical HK — Rejuran: 4 Benefits and Post-Treatment Precautions
• Rejuran Official Website Korea — Same Pharma
• MFDS Medical Device Information Portal